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Follicular Lymphoma Look-Alikes Follicular lymphoma: the nodules are tightly packed, fairly well-defined despite the absence of mantle zones, and homogeneous in size and shape. Proliferation centers in small lymphocytic lymphoma: the nodules are vague. Reactive follicular hyperplasia: the nodules are sharply defined with mantle zones (hard to see here at low power), loosely packed, and heterogeneous in size if not shape. Table of Contents