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Publications

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    2013

  1. Lin Yang, Xin Qi, Fuyong Xing, Tahsin Kurc, Joel Saltz, David J. Foran. Parallel content based sub-image retrieval using hierarchical searching. Bioinformatics, 2013. .
  2. Xin Qi, Daihou Wang, Javier Diaz-Montes, Ivan Rodero, Tony Pan, Abulimit Aji, Lee Cooper, Fuyong Xing, Manish Parashar, David J. Foran, Lin Yang. Exploring online nuclear segmentation on large fluorescence brain tumor images using CometCloud. High Performance Computing in Biomedical Image Analysis Associated with MICCAI 2013, Nagoya, Japan. pp.13-22.
  3. Daihou Wang, Xin Qi, Manish Parashar, David J. Foran, Lin Yang. High-throughput content-based image retrieval using GPGPU. High Performance Computing in Biomedical Image Analysis Associated with MICCAI 2013, Nagoya, Japan. pp.31-41.
  4. Xin Qi, Rebekah H. Gensure, David J. Foran, Lin Yang. Content-based white blood cell retrieval on bright-field pathology images. Proceeding of SPIE Medical Imaging 2013. Vol. 8676, March, 2013.
  5. Rajarshi Roy, Wenjin Chen, Lei Cong, Lauri A. Goodell, David J. Foran, Jaydev Desai. A Semi-Automated Positioning System for Contact-Mode Atomic Force Microscopy (AFM). IEEE Transactions on Automation Science and Engineering. Vol. 10, No. 2 April, 2013.

    2012

  1. Xin Qi, Hyunjoo Kim, Fuyong Xing , Manish Parashar, David J. Foran, Lin Yang . The Analysis of Image Feature Robustness Using CometCloud . Journal of Pathology Informatics . 2012; 3:33. doi: 10.4103/2153-3539.101782. Epub Sep 28, 2012 .
  2. William J Cukierski, Kaustav Nandy, Prabhakar Gudla, Karen J Meaburn, Tom Misteli, David J. Foran and Stephen J. Lockett. Ranked Retrieval of Segmented Nuclei for Objective Assessment of Cancer Gene Repositioning . BMC Bioinformatics . Sep 12; 13(1):232. [Epub ahead of print], 2012 .
  3. Rebekah H. Gensure, David J. Foran, Vincent M. Lee, Vyacheslav M. Gendel, Salma K. Jabbour, Darren R. Carpizo, John L. Nosher, Lin Yang. Evaluation of Hepatic Tumor Response to Yttrium-90 Radioembolization Therapy using Texture Signatures Generated from Contrast-enhanced CT Images . Academic Radiology . Oct; 19(10):1201-1207. Epub Jul 26, 2012 .
  4. Karl Miletti-Gonzalez, Kyle Murphy, Muthu N. Kumaran, Muthu N. Kumaran, Roman Wernyj, Swayamjot Kaur, Gregory D. Miles, Elaine Lim, Rigel Chan, Marina Chekmareva, Debra S. Heller, David J. Foran, Wenjin Chen, Michael Reiss, Elisa V. Bandera, Kathleen Scotto, Lorna Rodríguez-Rodríguez. Identification of a Function for the CD44-Intracytoplasmic Domain (CD44-ICD): Modulation of MMP-9 Transcription via a Novel Promoter Response Element . Journal of Biological Chemistry . Jun 1; 287(23):18995-9007. 2012 .
  5. Evita Sadimin and David J. Foran . Pathology Imaging Informatics for Clinical Practice and Investigative and Translational Research . North American Journal of Medical Sciences (NAJMS). Apr; 5(2):103-109, 2012 .
  6. X.Qi, F.Xing, M.Ghadge, I.Rodero, M.Abdelbaky, M.Parashar, E.Sadimin, D.J.Foran, L.Yang . Content-based Image Retrieval on Imaged Peripheral Blood Smear Specimens using High-Performance Computation . Workshop on Data-and Compute-intensive Clinical and Translational Image Applications. International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) . Nice, France, Vol 1: 51-60. 2012.
  7. Fuyong Xing, Xin Qi, David J. Foran, Tahsin Kurc, JoelSaltz, Lin Yang . Content-based Sub-image Retrieval . Workshop on Data-and Compute-intensive Clinical and Translational Image Applications. International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) . Nice, France, Vol 1: 61-70. 2012.
  8. Xin Qi, Fuyong Xing, David, J. Foran, Lin Yang. A fast, automatic segmentation algorithm for locating and delineating touching cell boundaries in imaged histopathology. Methods of Information in Medicine. Vol. 51, 260-267, 2012.
  9. Xin Qi, Fuyong Xing, David J. Foran, Lin Yang. Robust Segmentation of Overlapping Cells in Histopathology Specimens Using Parallel Seed Detection and Repulsive Level Set. IEEE Transactions on Medical Imaging. Vol. 59, No. 3, 754-765, 2012. (PDF)
  10. Fuyong Xing, Xin Qi, Baiyang Liu, David J. Foran, Lin Yang. Digitized tissue microarray classification using sparse reconstruction. Proceeding of SPIE Medical Imaging. No.8314-177, 2012.

    2011

  1. David J. Foran, Wenjin Chen, Lin Yang. Review Article, Modern Trends in Imaging IV: Automated image interpretation and computer-assisted diagnostics. Analytical Cellular Pathology. 34, 279-300, 2011. (PDF)
  2. Rajarshi Roy, Wenjin Chen, Lauri Goodell, Jun Hu, David J. Foran, Jaydev P. Desai. Microarray-facilitated Mechanical Characterization of Breast Tissue Pathology Samples using contact mode Atomic Force Microscopy (AFM). Third IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics - BioRob. September 26-29, 2010.
  3. Evita Sadimin, Wenjin Chen, Adena Osband, William Reitsma, David Laskow, Jaworski Joseph, Billie Fyfe. Telemicroscopy for the Evaluation of Donor Kidney Biopsies. Journal of Modern Pathology. 24 (sup1): 350A, 2011.
  4. Rajarshi Roy, Wenjin Chen, Lei Cong, Lauri Goodell, David J. Foran, Jaydev P. Desai. Towards Automated Mechanical Characterization of Biological Samples Using Atomic Force Microscopy (AFM). 4th Annual Dynamic Systems and Control Conference, Arlington, VA, USA. Oct 31 - Nov 2, 2011.
  5. Karine A. Cohen-Solal, Kim T. Merrigan, Joseph Chan, James S. Goydos, Wenjin Chen, David J. Foran, Fang Liu, Ahmed Lasfar, Michael Reiss. Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-ß-mediated growth inhibition. Pigment Cell and Melanoma Research. Vol. 24, Issue 3, 512–524, June 2011.
  6. David J. Foran, Lin Yang, Wenjin Chen, Jun Hu, Lauri A. Goodell, Michael Reiss, Fusheng Wang, Tahsin Kurc, Tony Pan, Ashish Sharma, Joel H. Saltz. ImageMiner: a software system for comparative analysis of tissue microarrays using content-based image retrieval, high-performance computing, and grid technology. Journal of the American Medical Informatics Association. Vol. 18, Issue 4, 403-415.
  7. Xin Qi, Fuyong Xing, David J. Foran and Lin Yang. Comparative performance analysis of stained histopathology specimens using RGB and multispectral imaging. Proc. SPIE Medical Imaging 2011: Computer-Aided Diagnosis, 2011. 7963.
  8. Xin Qi, Hyunjoo Kim, Fuyong Xing, Manish Parashar, David J. Foran and Lin Yang. The analysis of image texture feature robustness using CometCloud. High Performance Computing (HP) workshop associated with Proc. International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI). Toronto, Canada, 2011.
  9. Rebekah H. Gensure, Lin Yang, John L. Nosher, and David J. Foran. Evaluation of hepatic tumor response to SIRT therapy using texture feature signatures from contrast-enhanced CT images. Oral and poster presentation at the Cancer Imaging and Radiation Therapy Symposium 2011. Atlanta, GA. (PDF)

    2010

  1. Xin Qi, Yinsheng Pan, Michael V. Sivak, Joseph E. Willis, Gerard Isenberg and Andrew M. Rollins. Image analysis for classification of dysplasia in Barrett's esophagus using endoscopic optical coherence tomography. Biomedical Optics Express. Vol. 1, No.3, 825-847, 2010.
  2. Wei Kang, Xin Qi, Andrew M. Rollins, Nancy J. Tresser, Margarita Kareta and Jerome L. Belinson. Diagnostic efficacy of computer extracted image features in optical coherence tomography of precancerous cervix. Medical Physics. Vol. 38, Issue 1, 107-113, 2010.
  3. Xin Qi, Fuyong Xing, David J. Foran, and Lin Yang. GPU-Enabled Parallel Touching Cell Segmentation Using Mean-Shift Based Seed Detection and Repulsive Level Set.. The 2nd International Workshop on High-Performance Medical Image Computing for Image-Assisted Clinical Intervention and Decision-Making. Bejing, China. HP-MICCAI 2010 International Workshop. Pages 12-21, 2010. (PDF)
  4. Patrick Widener, Wenjin Chen, Fusheng Wang, Lin Yang, Jun Hu, Vicky Chu, Joel H. Saltz, David J. Foran, and Tahsin Kurc. Grid-Enabled, High-performance Microscopy Image Analysis. The 2nd International Workshop on High-Performance Medical Image Computing for Image-Assisted Clinical Intervention and Decision-Making. Bejing, China. HP-MICCAI 2010 International Workshop. Pages 70-79, 2010. (PDF)
  5. William J. Cukierski and David J. Foran. Metamerism in Multispectral Imaging of Histopathology Specimens. International Symposium on Biomedical Imaging (ISBI) 2010. 145 - 148. (PDF) http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?arnumber=5490392
  6. Baiyang Liu, Lin Yang, Casimir Kulikowski, Jinghao Zhou, Leiguang Gong, David J. Foran, Salma Jabbour and Ning Yue. An Adaptive Tracking Algorithm of Lung Tumors in Fluoroscopy Using Online Learned Collaborative Trackers. International Symposium on Biomedical Imaging (ISBI) 2010. 209 - 212. (PDF) http://www.ncbi.nlm.nih.gov/pubmed/20622932 http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?arnumber=5490376
  7. Xin Qi, William J. Cukierski and David J. Foran. A Comparative Performance Study Characterizing Breast Tissue Microarrays Using Standard RGB and Multispectral Imaging. SPIE Photonics West 2010. Proc. SPIE, Vol. 7557, 75570Z (2010). (PDF)
  8. Lauri Goodell, Wenjin Chen, P. Javidian, M. Chekmareva, Jun Hu, and David J. Foran. Use of computer assisted analysis to facilitate tissue microarray interpretation. United States and Canadian Academy of Pathology 2010 Annual Meeting Washington, D. C.. March 20–26, 2010.

    2009

  1. Hyunjoo Kim, Manish Parashar, David J. Foran, and Lin Yang. Investigating the use of Cloudbursts for High Performance Registration of Medical Images. IEEE/ACM International Conference on Grid Computing. 13-15 Oct. 2009, 34-41. (PDF) http://ieeexplore.ieee.org/Xplore/login.jsp?url=http%3A%2F%2Fieeexplore.ieee.org%2Fiel5%2F5347304%2F5353038%2F05353065.pdf%3Farnumber%3D5353065&authDecision=-203
  2. Lin Yang, Leiguang Gong, Hong Zhang, John L Nosher, and David J. Foran. A multicore based parallel image registration method. IEEE Engineering in Medicine and Biology Society (EMBS) 2009. 98-101. (PDF) http://www.ncbi.nlm.nih.gov/pubmed/19964921
  3. Lin Yang, Leiguang Gong, Hong Zhang, John L. Nosher and David J. Foran. A Parallel Point Matching Algorithm for Landmark-Based Image Registration Using Multicore Platform. European Conference on Parallel Computing. LNCS 5704, 2009, 936-47. (PDF)
  4. Hong Zhang, Lin Yang, David J. Foran, John L. Nosher and Peter J. Yim. 3-D Segmentation of the Liver using Free-Form Deformation based on Boosting and Deformation Gradients. International Symposium on Biomedical Imaging (ISBI). June 28-July 1, 2009. 494 - 497. (PDF) http://www.ncbi.nlm.nih.gov/pubmed/19997530 http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?tp=&arnumber=5193092
  5. William J. Cukierski, Xin Qi and David J. Foran. Moving Beyond Color: The Case for Multispectral Imaging in Bright-Field Pathology. International Symposium on Biomedical Imaging (ISBI). June 28-July 1, 2009. 1111-1114. http://www.ncbi.nlm.nih.gov/pubmed/19997528 http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?tp=&arnumber=5193251
  6. David J. Foran, Wenjin Chen, Lin Yang, Jun Hu, Tahsin Kurc, Renato Ferreira and Joel H. Saltz. A caGrid enabled, Learning-Based Segmentation Method for Histopathology Specimens. International Symposium on Biomedical Imaging (ISBI). June 28-July 1, 2009. 1111-1114. 1306 - 1309. (PDF) http://www.ncbi.nlm.nih.gov/pubmed/19936299 http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?tp=&arnumber=5193304
  7. Lin Yang, Wenjin Chen, Peter Meer, Michael D. Feldman, Lauri A. Goodell, Adam Bagg, Wei He, David J. Foran. PathMiner: A Web-Based Tool for Computer Assisted Diagnostics in Pathology. IEEE Transactions on Information Technology in Biomedicine. 2009 May;13(3): 291-9. (PDF) http://www.ncbi.nlm.nih.gov/pubmed/19171530
  8. Lin Yang, Wenjin Chen, Michael D. Feldman, Viktors Berstis, and David J. Foran. Virtual Microscopy and Grid-enabled Decision Support for Large-Scale Analysis of Image Pathology Specimens. IEEE Transactions on Information Technology in Biomedicine. Volume 13, Issue 4 (July 2009). 636-644. (PDF) http://www.ncbi.nlm.nih.gov/pubmed/19369162
  9. Gabriela Niculescu, John L. Nosher, David J. Foran. A Deformable Model for Tracking Tumors across Consecutive Imaging Studies. International Journal of Computer Assisted Radiology and Surgery. Volume 4, Number 4, June, 2009. 337-347. http://www.ncbi.nlm.nih.gov/pubmed/19774096
  10. Rajarshi Roy, Wenjin Chen, Jun Hu, Lauri Goodell, David J. Foran, Jaydev P. Desai. Tissue Microarray Facilitated Mechanical Characterization of Cancerous Breast Tissue using Atomic Force Microscopy. Advanced Practice, Instruction and Innovation through Informatics (APIII). September 2009.

    2008

  1. Lin Yang, Bogdan Georgescu, Yefeng Zheng, David J. Foran, Dorin Comaniciu. A Fast and Accurate Tracking Algorithm of Left Ventricles in 3-D Echocardiography. IEEE Proceedings of the International Symposium on Biomedical Imaging. 221-224. 2008. http://www.ncbi.nlm.nih.gov/pubmed/19936301
  2. William J. Cukierski and David J. Foran. Using Betweenness Centrality to Identify Manifold Shortcuts. Proceedings of IEEE International Conference on Data Mining, Analysis of Dynamic Networks. ICDMW, 949-958. (PDF) http://www.ncbi.nlm.nih.gov/pubmed/20607142 http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?arnumber=4734026
  3. Lin Yang, Bogdan Georgescu, Yefeng Zheng, Peter Meer, David J. Foran and Dorin Comaniciu. An Automatic, Robust and Fast-Tracking of Heart Motion in 3-D Ultrasound and CT Images. IEEE Transaction on Medical Imaging. In submission.
  4. Gabriela Niculescu, John L. Nosher, David J. Foran. 3-D Morphometry and Non-Rigid Registration for Quantitative Analysis and Clinical Assessment in Radiology. . In Review.
  5. Lin Yang, Peter Meer, David J. Foran. Automatic Image Analysis of Histopathology Specimens Using Concave Vertex Graph. Proc. International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI). New York, US, September 2008. http://www.ncbi.nlm.nih.gov/pubmed/18979823
  6. Bonnie H. Hall, Monica Ianosi-Irimie, Parisa Javidian, Wenjin Chen, Shridar Ganesan, David J. Foran. Computer Assisted Assessment of the Human Epidermal Growth Factor Receptor 2 Immunohistochemical Assay in Histologic Sections Using a Membrane Isolation Algorithm and Quantitative Analysis of Positive Controls. BMC Medical Imaging. Vol8:11, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18534031
  7. Robert S. DiPaola, Dmitri Dvorzhinski, Anu Thalisila, Venkata Garikapaty, Michael May, K. Bray, Brian Beaudoin, C. Karp, Wenjin Chen, David J. Foran, Eileen White. Therapeutic Starvation and Autophagy in Prostate Cancer: A New Paradigm for Targeting Metabolism in Cancer Therapy. Prostate. 2008 Dec 1;68(16):1743-52. http://www.ncbi.nlm.nih.gov/pubmed/18767033
  8. Wenjin Chen, Gratian Salaru, David J. Foran. Computer Assisted Microscopy (CAM): Robotic Microscopy with Applications in Unsupervised Specimen Analysis and Telemedicine. . In review.
  9. Lin Yang, Bogdan Georgescu, Yefeng Zheng, David J. Foran, Dorin Comaniciu. A Fast and Accurate Tracking Algorithm of Left Ventricles in 3-D Echocardiography. International Symposium on Biomedical Imaging (ISBI). 14-17 May 2008. 221 - 224. http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?tp=&arnumber=4540972&isnumber=4540908
  10. David J. Foran and John L. Nosher. Multivariate Tracking of Hepatic Neoplasms for Improved Therapy Planning. . In review.

    2007

  1. Wenjin Chen and David J. Foran. A computer-assisted microscopy system for automated image analysis of pathology specimens and tissue microarrays. Book Chapter - Image Analysis in Medicinal Microscopy and Pathology. ISBN 81-308-0116-7, 2007.
  2. Gabriela Niculescu, John L. Nosher, David J. Foran. Non-rigid Registration of the Liver in Consecutive CT Studies for Assessment of Tumor Response to Radiofrequency Ablation. IEEE Proceedings of the Engineering in Medicine and Biology Society. 856-9, 2007. http://www.ncbi.nlm.nih.gov/pubmed/18002091
  3. Bonnie H. Hall, Wenjin Chen, and David J. Foran. A Clinically Motivated 2-Fold Framework for Quantifying and Classifying of Immunohistochemically Stained Specimens.Proceedings on Medical Image Computing and Computer-Assisted Intervention. Proceedings on Medical Image Computing and Computer-Assisted Intervention (MICCAI). Vol. 10:2; 287-94, 2007. http://www.ncbi.nlm.nih.gov/pubmed/18044580
  4. Lin Yang, Peter Meer, Lauri A. Goodell, Michael D. Feldman, and David J. Foran. High-Throughput Breast Cancer Analysis on the Grid. Proceedings on Medical Image Computing and Computer-Assisted Intervention (MICCAI). Vol. 10:2;617-25, 2007. (PDF) http://www.ncbi.nlm.nih.gov/pubmed/18051110
  5. Lin Yang, Wenjin Chen, Michael D. Feldman, Viktors Berstis, and David J. Foran. Virtual Microscopy and Grid-enabled Decision Support for Large-Scale Analysis of Image Pathology Specimens. . In review.
  6. Lin Yang, Peter Meer, David J. Foran. Multiple Class Segmentation Using A Unified Framework over Mean-Shift Patches. IEEE Proceedings on Computer Vision and Pattern Recognition. 2007 Jul 16;2007(4270254):1-8. http://www.ncbi.nlm.nih.gov/pubmed/19295664
  7. Oncel Tuzel, Lin Yang, Peter Meer, David J. Foran. Classification of Hematologic Malignancies Using Texton Signatures. Pattern Analysis and Applications. 10, 277-290, 2007. http://www.ncbi.nlm.nih.gov/pubmed/19890460

    2006

  1. Lin Yang and David J. Foran. A Variational Framework for Partially Occluded Image Segmentation Using Coarse to Fine Shape Alignment and Semi-parametric Density Approximation. IEEE Proceedings on Image Processing. 2006;1(4378885):137-140. http://www.ncbi.nlm.nih.gov/pubmed/19305512
  2. Wenjin Chen, Cristina Schmidt, Manish Parashar, Michael Reiss, David J. Foran. Decentralized Data Sharing of Tissue Microarrays for Investigative Research in Oncology. Cancer Informatics. Vol. 2: 373–388, 2006. http://www.ncbi.nlm.nih.gov/pubmed/19081778
  3. Wenjin Chen and David J. Foran. Advances in Tissue Microarray Technology: Towards Improved Understanding and Diagnosis of Cancer. Analytica Chimica Acta. Vol. 5:1; 74-81. 2006. (PDF) http://www.ncbi.nlm.nih.gov/pubmed/17723364

    2005

  1. Lin Yang, Peter Meer, David J. Foran. Unsupervised Segmentation Based on Robust Estimation and Color Active Contour Models. IEEE Trans. on Information Technology in Biomedicine. 2005 Sep;9(3):475-86. (PDF) http://www.ncbi.nlm.nih.gov/pubmed/16167702
  2. Wenjin Chen, Peter Meer, Bogdan Georgescu, Wei He, Lauri A. Goodell, David J. Foran. Image Mining for Investigative Pathology Using Optimized Feature Extraction and Data Fusion. Computer Methods and Programs in Biomedicine. Volume 79, Issue 1, Pages 59-72, 2005. (PDF)

    Pre-2005

  1. Wenjin Chen, Michael Reiss, and David J. Foran. Unsupervised Tissue Microarray Analysis for Cancer Research and Diagnostics. IEEE Transactions on Information Technology in Biomedicine. Vol. 8: No. 2, pages 89-96. 2004. (PDF)
  2. Wei Lin, Joseph Wilder, and David J. Foran. A Network-Reactive Model for Telemicroscopy. Journal of Telemedicine and Telecare. Vol. 9, No. 2, pp. 78-83, 2003. (PDF)
  3. Wenjin Chen, David J. Foran, and Michael Reiss. Unsupervised Imaging, Registration and Archiving of Tissue Microarrays. Proceedings of the American Medical Informatics Association. Vol. 1: 136-139, 2002. (PDF)
  4. Gabriela Niculescu, Louay Toni, David J. Foran, John L. Nosher, Kevin J. DeMarco. Dynamic Imaging Database for 3D Morphologic Analysis and Clinical Assesssment in Diagnostic Radiology. AMIA. 2002. (PDF)
  5. David J. Foran, Dorin Comaniciu, Peter Meer, and Lauri A. Goodell. Computer Assisted Discrimination Among Malignant Lymphomas and Leukemia Using Immunophentyping, Intelligent Image Repositories and Telemicroscopy. IEEE Trans. On Information Technology in Biomedicine. Vol. 4:4, pages 265-273. 2000. (PDF)
  6. Dorin Comaniciu, Peter Meer, David J. Foran. Image Guided Decision Support System for Pathology. Machine Vision and Applications. Vol. 11:4, pages 213-224. 1999. (PDF)
  7. Dorin Comaniciu, Wenjin Chen, Peter Meer, David J. Foran. Multiuser Workspaces for Remote Microscopy in Telepathology. IEEE Proceedings on Computer-Based Medical Systems. Vol. 1, pages 150-156, 1999. (PDF)
  8. Dorin Comaniciu, David J. Foran, and Peter Meer. Shape-Based Image Indexing and Retrieval for Diagnostic Pathology. IEEE Proceedings on Pattern Recognition. Vol. 1, pages 902-905, 1998. (PDF)
  9. Dorin Comaniciu, Peter Meer, Attila Medl, David J. Foran. Bimodal System for Interactive Indexing and Retrieval of Pathology Images. IEEE Proceedings on Computer Vision. Vol. 1, pages 76-81, 1998. (PDF)
  10. David J. Foran , Peter Meer, Thomas V. Papathomas, and Ivan Marsic. Compression Guidelines for Diagnostic Telepathology. IEEE Transactions on Information Technology in Biomedicine. Vol. 1, pages 55-60, 1997. (PDF)